Dr. Granger’s primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. He has led a number of large international clinical studies in heart attacks, unstable angina, heart failure, and atrial fibrillation. Additionally, he has lead clinical studies of blood thinners and coronary intervention for heart attacks, stroke prevention in atrial fibrillation, and prevention of heart attack for patients with coronary artery disease. Dr. Granger has been co-director of the Reperfusion of Acute MI in Carolina Emergency Departments (RACE) project that is a North Carolina state-wide program to improve reperfusion care for acute myocardial infarction. He currently serves as the Chairman of the American Heart Association Mission: Lifeline program to improve heart attack care nationally as well as the American College of Cardiology/American Heart Association guideline committee for heart attack care. He has also studied the effects of genetic variation on heart disease and works with the National Institute of Health and the Federal Drug Administration on evaluation of heart disease and of new drugs. Additionally, Dr. Granger has developed tools to predict which patients are at risk for death, heart attack, and need for hospitalization.